In FusionFall, Gwen can be found at the Pimpleback Mountains. When spoken to, she sometimes mentions getting constant e-mails from someone in Nowhere who knows about alien activity (it can easily be guessed that this is either Courage or Kevin). Her missions mainly involve the Totem plotline in which she sends the player to activate the totems spread across Downtown and the Wilds, which supposedly act as a self-defense mechanism.
Gwen can also be found inside of Ship, giving out the mission "Gwen's Gambit" and a Gwen 10,000 hood and shirt. She is mainly responsible for creating the portals that the player uses to infiltrate Vilgax's ship and providing the platforms that must be used to navigate the said ship.
- When the game was first released, Gwen's model had her original appearance in Alien Force. Once Season 3 of the series began airing, her model and those of Kevin and Vilgax were at that time changed to their current appearances. She and Kevin have so far not been updated with their Ben 10: Ultimate Alien appearances or Ben 10: Omniverse appearances.
- While Gwen was majorly involved in the Totem plotline, Fusion Gwen was also involved with the arc.